It is an emerging branch of pharmacology, whose main objective is to study the effects caused by the physicochemical formula and the form of drugs on pharmacodynamic and pharmacokinetic events after their use. In recent decades, this science has gained space and great importance, all thanks to the inevitable need to carry out bioequivalence studies of interchangeable generic drugs.
The objective of the study of biopharmacy lies in determining the most appropriate amounts or doses, in addition to the intervals between doses for the optimal administration of drugs. On the other hand, it also allows us to know and make the most precise calculations on the concentration of drugs in the different organs of the body, in order to establish an ideal therapeutic regimen.
The characteristic processes of the development of a drug after its administration in a given organism under specific conditions and under a strict administration regimen are known by the acronym LADME, whose acronym comes from the steps through which the drug can pass during the passage of the drug. drug by the body, the The first of these steps is drug release, the second is absorption, followed by distribution, leading to metabolism and finally excretion.
The release refers to the release of the drug from its pharmaceutical presentation, generally this process dilutes the drug in some medium of the body, through the proper application of certain pharmacological technical processes, the speed with the release of the drug can be controlled.
Absorption, during this process it can be said that it is when the drug actually enters the body, where it crosses different membranes, before reaching the systemic circulation.
Distribution, after the drug enters the circulatory system, it spreads throughout the body through the blood, once the drug is in the vascular space, it can bind to plasma proteins, and also pass through the erythrocytes between other cells.
Metabolization, in this phase the drug will undergo certain changes in its structure, this due to the effect of the enzyme systems of the organism, with this it will be possible to obtain the metabolites a little more soluble in water and with less activity than at the beginning.
Excretion, after the drug enters the circulatory system, the body detects the foreign substances and initiates the various processes for their elimination.
